Adult height in Turkish patients with Turner syndrome without growth hormone treatment.
نویسندگان
چکیده
Spontaneous adult height (AH) in Turner syndrome (TS) varies among populations. Population-specific AH data is essential to assess the efficacy of growth-promoting therapies in TS. A multicenter study was performed to establish AH of nongrowth hormone (GH)-treated Turkish patients with TS. One hundred ten patients with TS (diagnosed by karyotype) who reached AH (no growth in the previous year, or bone age > 15 years) without receiving GH treatment were included in the study. The average AH was found to be 141.6 +/- 7.0 cm at the age of 22.9 +/- 6.2 years, which is 18.4 cm below the population average and 16.4 cm below the patients' mid-parental heights. Bone age at start of estrogen replacement was 12.3 +/- 1.3 year. Karyotype distribution of the patients was 45X (43%), 45X/46XX (16%), 45X/46Xi (12%), 45XiXq (10%) and others (19%). When the patients were evaluated according to their karyotype as 45X and non-45X, no significant difference in AH was observed (142.4 +/- 6.9 cm vs 140.9 +/- 7.1 cm, respectively). Adult height of non-GH-treated Turkish TS patients obtained in this study was comparable to that of other Mediterranean populations, but shorter than that of Northern European patients. Karyotype does not seem to affect AH in TS.
منابع مشابه
Effect of oxandrolone therapy on adult height in Turner syndrome patients treated with growth hormone: a meta-analysis
Turner syndrome is a chromosomal abnormality in which there is complete or partial absence of the X chromosome. Turner syndrome effects 1 in every 2000 live births. Short stature is a cardinal feature of Turner Syndrome and the standard treatment is recombinant human growth hormone. When growth hormone is started at an early age a normal adult height can be achieved. With delayed diagnosis youn...
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Background Turner syndrome (TS) occurs in one 2000-2500 live female births and is associated with short stature, premature ovarian failure, and a range of other phenotypic features. Girls with TS achieve an average adult height 20cm shorter than their mid-parenteral height if they didn’t receive treatment. Growth hormone (GH) treatment was associated with highly significant gains in growth and ...
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ورودعنوان ژورنال:
- The Turkish journal of pediatrics
دوره 50 5 شماره
صفحات -
تاریخ انتشار 2008